The Mysterious World of Isozymes
نویسنده
چکیده
Strictly defined, isozymes are similar forms of the same enzyme that share identical functions. There are different types of isozymes that are classified according to their origin isozymes may be encoded by several different loci (which determine subunit structure), or they may be determined by a single locus with several different alleles. If the latter, isozymes are referred to as "allozymes" (sometimes used interchangeably with "isozymes"). Many well-known enzymes and their isozymes used in electrophoretic studies function in the metabolic pathway. For example, glucophosphoisomerase (GPI or PGI) catalyzes the second step of glycolysis, by converting glucose-6-phosphate to fructose-6-phosphate. Isocitrate dehydrogenase (IDH) and malate dehydrogenase (MDH) both function in the TCA cycle.
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